Epigentek-47

TWNK Polyclonal Antibody A69095

TWNK Polyclonal Antibody
A69095-020 20 µg
A69095-050 50 µg  
A69095-100 100 µg
Product Overview
 

Background
Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.

Description
TWNK Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, pH 7.4.

Specificity
Human

Isotype
IgG

Uniprot ID
Q96RR1

Purification
>95%, Protein G purified

Immunogen
Recombinant Human Twinkle protein, mitochondrial protein (559-684AA)

Storage
Shipped at 4°C. Upon receipt, store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
Twinkle protein, mitochondrial, Progressive external ophthalmoplegia 1 protein, T7 gp4-like protein with intramitochondrial nucleoid localization, T7-like mitochondrial DNA helicase, Twinkle mtDNA helicase, TWNK

Application
ELISA, IHC; Recommended dilution: IHC:1:500-1:1000